Is salmon DNA microneedling safe?

Yes. PDRN (polynucleotide) therapy has been used in wound healing and regenerative medicine for years. The salmon DNA is highly purified and biocompatible with human tissue. At MDW Aesthetics, all treatments are performed under medical direction.

How does salmon DNA microneedling differ from PRP microneedling?

PRP uses your own blood platelets for growth factors. Salmon DNA uses purified polynucleotides (PDRN) from salmon to stimulate cell repair at the DNA level. Both enhance microneedling results, but through different biological pathways.

How many salmon DNA microneedling sessions do I need?

Most patients see significant improvement after 3-4 sessions spaced 4 weeks apart. At MDW Aesthetics in Brickell, your practitioner creates a customized treatment plan based on your skin concerns and goals.

Salmon DNA Microneedling Miami | MDW

Salmon DNA microneedling combines traditional microneedling with polynucleotide (PDRN) therapy to accelerate skin repair at the cellular level. PDRN, derived from purified salmon DNA, acts as a biological stimulant that tells your skin cells to regenerate faster, produce more collagen, and improve hydration from within. At MDW Aesthetics in Brickell, this treatment starts at $499.

If you've heard about "salmon DNA facials" trending across Miami and wondering whether the science supports the hype, this guide breaks down exactly what PDRN is, how it works alongside microneedling, and how it compares to PRP-enhanced treatments.

What Is PDRN (Polynucleotide) Therapy?

PDRN stands for polydeoxyribonucleotide, a bioactive compound extracted from salmon DNA that stimulates cell regeneration, collagen production, and tissue repair when applied to the skin.

PDRN is not a new discovery. It has been used in medical settings for wound healing and tissue regeneration for over a decade. What's relatively new is its application in aesthetic medicine, where it has gained significant attention for its ability to improve skin quality at a fundamental level.

Here is how PDRN works in the skin:

Activates the A2A adenosine receptor: This receptor plays a key role in anti-inflammatory responses and tissue repair. When PDRN binds to it, the cell receives a signal to begin regeneration.
Stimulates fibroblast activity: Fibroblasts are the cells responsible for producing collagen and elastin. PDRN increases their activity, leading to more collagen production.
Promotes angiogenesis: PDRN encourages new blood vessel formation, improving nutrient and oxygen delivery to the treatment area.
Reduces inflammation: PDRN has anti-inflammatory properties that reduce post-treatment redness and accelerate recovery.

How Salmon DNA Microneedling Works

The microneedling device creates thousands of microchannels in the skin, then PDRN solution is applied topically and absorbed directly through these channels for maximum cellular absorption.

The treatment combines two powerful mechanisms:

Microneedling (collagen induction therapy): Tiny needles create controlled micro-injuries that trigger the body's natural wound healing response, stimulating new collagen and elastin production.
PDRN delivery: The PDRN solution, applied immediately after microneedling, penetrates deep into the skin through the open microchannels. This targeted delivery maximizes absorption compared to surface-only application.

"Think of microneedling as opening the doors, and PDRN as the repair crew that walks through them," explains Dr. Mina Ayad, Medical Director at MDW Aesthetics. "The combination produces results that neither treatment achieves alone."

Salmon DNA vs PRP Microneedling: Key Differences

PRP uses your own growth factors from blood. Salmon DNA uses external polynucleotides. Both enhance microneedling, but through different biological pathways that complement rather than compete with each other.

Feature	PRP Microneedling	Salmon DNA Microneedling
Source	Your own blood	Purified salmon DNA
Active compound	Growth factors (PDGF, VEGF, TGF)	Polynucleotides (PDRN)
Mechanism	Growth factor stimulation	A2A receptor activation + cell repair
Blood draw required	Yes	No
Anti-inflammatory	Moderate	Strong
Best for	Scars, texture, general rejuvenation	Hydration, fine lines, skin quality
Price at MDW	$499	$499

Both treatments are available at MDW Aesthetics, and we recommend one over the other based on your primary skin concerns. PRP microneedling excels for acne scarring and texture correction. Salmon DNA microneedling shines for overall skin quality, hydration, and fine line reduction.

Who Should Consider Salmon DNA Microneedling in Miami?

Ideal candidates include patients with dehydrated skin, early aging signs, sun-damaged skin from Miami's UV exposure, and anyone seeking a hydration and glow boost beyond what standard microneedling provides.

This treatment is particularly well-suited for Miami patients because:

Year-round UV exposure creates cumulative DNA damage in skin cells. PDRN helps repair this damage at the cellular level.
Humidity fluctuations and air conditioning in Brickell offices create skin dehydration that PDRN addresses from within.
Patients who have responded well to standard microneedling but want enhanced results often find PDRN delivers the next level of improvement.

Curious whether salmon DNA or PRP microneedling is right for your skin? Schedule a complimentary consultation at MDW Aesthetics in Brickell or call (786) 788-8626.

This content is for informational purposes only and does not substitute for professional medical advice. Results vary by individual. Consult with a qualified provider before undergoing any treatment.